GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Col1a1 | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of COL1A1 mRNA; Oxygen deficiency results in increased expression of COL1A1 protein | PMID:11981751 | Col1a1 | multiple interactions | EXP | | 6480464 | CTD | [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of COL1A1 mRNA]; [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of COL1A1 mRNA; [Paraquat co-treated with Oxygen] results in increased expression of COL1A1 mRNA | PMID:12882763 PMID:33729688 | Col1a1 | increases expression | ISO | Col1a1 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of COL1A1 mRNA; Oxygen results in increased expression of COL1A1 mRNA | PMID:21439370 PMID:22363622 PMID:24205000 | Col1a1 | increases expression | ISO | COL1A1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of COL1A1 mRNA; Oxygen results in increased expression of COL1A1 mRNA | PMID:21439370 PMID:23517783 PMID:24236059 | Col1a1 | increases secretion | ISO | COL1A1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased secretion of COL1A1 protein | PMID:23423382 | Col1a1 | multiple interactions | ISO | Col1a1 (Mus musculus) | 6480464 | CTD | Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] | PMID:21439370 | Col1a1 | multiple interactions | ISO | COL1A1 (Homo sapiens) | 6480464 | CTD | Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA]; HIF1A protein affects the reaction [Oxygen deficiency results in increased secretion of COL1A1 protein]; RHOA protein affects the reaction [Oxygen results in increased expression of COL1A1 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] | PMID:21439370 PMID:23423382 PMID:23517783 | | ||||||||||||||||||||||
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