GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of IL1B mRNA; Oxygen deficiency results in increased expression of IL1B protein | PMID:12829860 PMID:16368379 PMID:18635243 PMID:21296072 PMID:24223152 PMID:28983604 | Il1b | multiple interactions | EXP | | 6480464 | CTD | [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein; [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased secretion of IL1B protein; [Antagomirs results in decreased expression of MIR30C1 mRNA] promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein]; [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Oxygen] results in increased secretion of IL1B protein; [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]; iodopravadoline inhibits the reaction [peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]]; Mifepristone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; MIR30C1 mRNA inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein; peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]; PHLDA3 protein promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein]; PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased secretion of IL1B protein]; RSVA314 inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; RSVA405 inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; sanggenone C inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; SDC2 protein promotes the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein] | PMID:12829860 PMID:16368379 PMID:18635243 PMID:18803305 PMID:21296072 PMID:24223152 PMID:25214260 PMID:26464617 PMID:27064547 PMID:28983604 PMID:29560022 PMID:30229846 PMID:30611788 PMID:31935362 PMID:34217758 PMID:34351043 PMID:35191607 | Il1b | affects expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Oxygen affects the expression of IL1B mRNA | PMID:9555576 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of IL1B protein; Oxygen results in increased expression of IL1B mRNA | PMID:10781441 PMID:24223152 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of IL1B mRNA | PMID:24236059 PMID:26974319 PMID:29685624 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased secretion of IL1B protein | PMID:26974319 PMID:29685624 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein; [CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein; genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; sodium bisulfide inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein] | PMID:16872633 PMID:24223152 PMID:28477916 PMID:29560022 PMID:31283913 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; [IL1B protein co-treated with Oxygen deficiency] results in increased degradation of NFKBIA protein; [Oxygen deficiency co-treated with IL1B protein] results in increased expression of TNF protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]]; cobaltiprotoporphyrin inhibits the reaction [[Oxygen deficiency co-treated with IL1B protein] results in increased expression of TNF protein]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]; cobaltiprotoporphyrin promotes the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [[Oxygen deficiency co-treated with IL1B protein] results in increased expression of TNF protein]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]]]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]; KC7F2 compound inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; KC7F2 compound inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; Oxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of IL1B mRNA]; Oxygen deficiency inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Oxygen deficiency inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] | PMID:14652683 PMID:22535156 PMID:23406266 PMID:26974319 PMID:29685624 | |
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