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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDOxygen deficiency results in increased expression of IL1B mRNA; Oxygen deficiency results in increased expression of IL1B proteinPMID:12829860 PMID:16368379 PMID:18635243 PMID:21296072 PMID:24223152 PMID:28983604
Il1bmultiple interactionsEXP 6480464CTD[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein; [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased secretion of IL1B protein; [Antagomirs results in decreased expression of MIR30C1 mRNA] promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein]; [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Oxygen] results in increased secretion of IL1B protein; [Thiazoles analog binds to indoline analog] promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]; iodopravadoline inhibits the reaction [peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]]; Mifepristone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; MIR30C1 mRNA inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein]; MK 2206 promotes the reaction [PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein; peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]; PHLDA3 protein promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of IL1B protein]; PHLDA3 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased secretion of IL1B protein]; RSVA314 inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; RSVA405 inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; sanggenone C inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; SDC2 protein promotes the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein]PMID:12829860 PMID:16368379 PMID:18635243 PMID:18803305 PMID:21296072 PMID:24223152 PMID:25214260 PMID:26464617 PMID:27064547 PMID:28983604 PMID:29560022 PMID:30229846 PMID:30611788 PMID:31935362 PMID:34217758 PMID:34351043 PMID:35191607
Il1baffects expressionISOIl1b (Mus musculus)6480464CTDOxygen affects the expression of IL1B mRNAPMID:9555576
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDOxygen deficiency results in increased expression of IL1B protein; Oxygen results in increased expression of IL1B mRNAPMID:10781441 PMID:24223152
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of IL1B mRNAPMID:24236059 PMID:26974319 PMID:29685624
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDOxygen deficiency results in increased secretion of IL1B proteinPMID:26974319 PMID:29685624
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein; [CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased expression of IL1B protein; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein; genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; peoniflorin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; sodium bisulfide inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]PMID:16872633 PMID:24223152 PMID:28477916 PMID:29560022 PMID:31283913
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; [IL1B protein co-treated with Oxygen deficiency] results in increased degradation of NFKBIA protein; [Oxygen deficiency co-treated with IL1B protein] results in increased expression of TNF protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]]; cobaltiprotoporphyrin inhibits the reaction [[Oxygen deficiency co-treated with IL1B protein] results in increased expression of TNF protein]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]; cobaltiprotoporphyrin promotes the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [[Oxygen deficiency co-treated with IL1B protein] results in increased expression of TNF protein]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]]]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of SOX9 protein]; KC7F2 compound inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; KC7F2 compound inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; Oxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of IL1B mRNA]; Oxygen deficiency inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Oxygen deficiency inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]PMID:14652683 PMID:22535156 PMID:23406266 PMID:26974319 PMID:29685624
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