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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDOxygen deficiency results in decreased expression of BAX proteinPMID:26476374 PMID:31930969 PMID:36940862
Baxincreases expressionEXP 6480464CTDOxygen deficiency results in increased expression of BAX mRNA; Oxygen deficiency results in increased expression of BAX proteinPMID:25450231 PMID:25937560 PMID:26476374 PMID:28983604 PMID:33413359
Baxmultiple interactionsEXP 6480464CTD(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; 4-phenylbutyric acid inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of BAX protein; [Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; kaempferol inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein]; Quercetin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; sanggenone C inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of BAX protein]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]PMID:23451161 PMID:25305180 PMID:25450231 PMID:25937560 PMID:26476374 PMID:28983604 PMID:30611788 PMID:31930969 PMID:31935362 PMID:33413359 PMID:36940862
Baxaffects expressionISOBax (Mus musculus)6480464CTDOxygen deficiency affects the expression of BAX proteinPMID:24680926
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of BAX mRNAPMID:29690507
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein; [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of BAX mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein modified form; HIF1A protein affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; HIF1A protein affects the reaction [MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]]; MIR186 mRNA affects the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; MIR186 mRNA inhibits the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of BAX protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; SIRT7 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; U 0126 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]PMID:24682241 PMID:25238743 PMID:28675767 PMID:30529165 PMID:33759271
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Oxygen deficiency results in increased expression of HIF1A protein] which affects the expression of BAX protein; NDRG2 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]; Oxygen deficiency promotes the reaction [HIF1A mutant form results in increased expression of BAX]PMID:20206160 PMID:23451161 PMID:24860939
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