GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | increases cleavage | EXP | | 6480464 | CTD | Oxygen deficiency results in increased cleavage of PARP1 protein | PMID:11042672 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride affects the susceptibility to Oxygen deficiency] which results in increased expression of PARP1 protein; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of PARP1 protein; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of PARP1 protein modified form; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]; KEAP1 protein inhibits the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of PARP1 protein modified form]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]]; Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein] | PMID:11042672 PMID:17131054 PMID:22639866 PMID:25221900 PMID:29605020 PMID:35191607 | Parp1 | increases activity | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased activity of PARP1 protein | PMID:27288104 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased cleavage of PARP1 protein; Oxygen results in increased cleavage of PARP1 protein | PMID:20530905 PMID:25831079 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of PARP1 protein modified form | PMID:26540049 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein; [Betulinic Acid co-treated with Oxygen] results in increased cleavage of PARP1 protein; [Glucose co-treated with Oxygen deficiency] results in increased activity of PARP1 protein; AHR mutant form promotes the reaction [Oxygen results in increased cleavage of PARP1 protein]; betulin analog promotes the reaction [Oxygen deficiency results in increased expression of PARP1 protein modified form]; N-ethoxymethyl-3-amino-1,2,4-benzotriazine-1,4-dioxide promotes the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein]; Oxygen deficiency inhibits the reaction [nickel monoxide analog results in increased cleavage of PARP1 protein] | PMID:20530905 PMID:25831079 PMID:26540049 PMID:27270449 PMID:27288104 PMID:33181113 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | PARP1 gene mutant form inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CXCL1 protein] | PMID:15696051 | | ||||||||||||||||||||||
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