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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617626
Species: Mus musculus
RGD Object: Gene
Symbol: Hbb-b1
Name: hemoglobin, beta adult major chain
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hbb-b1affects bindingISOHBB (Homo sapiens)6480464CTDHBB protein binds to Oxygen; HBB protein polymorphism binds to OxygenPMID:5773089
Hbb-b1multiple interactionsISOHBB (Homo sapiens)6480464CTD[voxelotor binds to and affects the folding of and results in increased stability of HBB protein] promotes the reaction [HBB protein binds to Oxygen]; [voxelotor binds to and affects the folding of HBB protein mutant form] promotes the reaction [HBB protein mutant form binds to Oxygen]PMID:30655275 PMID:33489427
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