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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10681
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases expressionEXP 6480464CTDOxygen results in decreased expression of GPX1 proteinPMID:35848756
Gpx1decreases response to substanceEXP 6480464CTDGPX1 protein results in decreased susceptibility to OxygenPMID:18638544
Gpx1multiple interactionsEXP 6480464CTDGPX1 protein inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]; MIR34C promotes the reaction [Oxygen results in decreased expression of GPX1 protein]PMID:17087917 PMID:35848756
Gpx1decreases activityISOGpx1 (Rattus norvegicus)6480464CTDOxygen results in decreased activity of GPX1 proteinPMID:15680347
Gpx1increases expressionISOGpx1 (Rattus norvegicus)6480464CTDOxygen results in increased expression of GPX1 mRNAPMID:15680347
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