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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10615
Species: Mus musculus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1decreases expressionEXP 6480464CTDOxygen deficiency results in decreased expression of GAD1 mRNAPMID:29107683
Gad1multiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein]; Dizocilpine Maleate inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein]; Oxygen deficiency results in decreased expression of and results in increased degradation of GAD1 proteinPMID:29107683
Gad1increases expressionISOGAD1 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of GAD1 mRNAPMID:26516004
Gad1multiple interactionsISOGad1 (Rattus norvegicus)6480464CTDGAD1 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]PMID:25966616
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