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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10297
Species: Mus musculus
RGD Object: Gene
Symbol: Cbs
Name: cystathionine beta-synthase
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbsincreases expressionEXP 6480464CTDOxygen results in increased expression of CBS proteinPMID:27273718
Cbsmultiple interactionsEXP 6480464CTD[CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased acetylation of RELA protein; [CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased expression of IL1B protein; [CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased expression of IL6 protein; [CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased expression of TNF protein; CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]PMID:31283913
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