Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:15372
Term: 5,6,7,8-tetrahydrobiopterin
Definition: A biopterin that has formula C9H15N5O3.
Chemical ID: MESH:C003402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3increases activityISORGD:7356186480464CTDsapropterin results in increased activity of NOS3 protein

PMID:23753407
Nos3multiple interactionsISORGD:109976480464CTD[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]

PMID:25490417
Nos3multiple interactionsISORGD:7356186480464CTDsapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides] sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]

PMID:19011239
Go Back to source page   Continue to Ontology report