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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2559
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:15372
Term: 5,6,7,8-tetrahydrobiopterin
Definition: A biopterin that has formula C9H15N5O3.
Chemical ID: MESH:C003402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epoincreases abundanceISORGD:105316480464CTDEPO protein results in increased abundance of sapropterin

PMID:25490417
Epomultiple interactionsISORGD:105316480464CTDEPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7 8-dihydrobiopterin] EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin]

PMID:25041251 PMID:25490417
Epomultiple interactionsISORGD:7358496480464CTDEPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]

PMID:25041251
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