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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9increases activityEXP 6480464CTDAcrolein results in increased activity of CASP9 proteinPMID:19596284
CASP9increases cleavageEXP 6480464CTDAcrolein results in increased cleavage of CASP9 proteinPMID:29902662 PMID:29964147
CASP9multiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of CASP9 protein]PMID:29902662 PMID:29964147
CASP9decreases activityISOCasp9 (Mus musculus)6480464CTDAcrolein results in decreased activity of CASP9 proteinPMID:11803030
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