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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDAcrolein results in increased expression of BAX mRNA; Acrolein results in increased expression of BAX proteinPMID:29414845
Baxmultiple interactionsEXP 6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of BAX mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of BAX protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]; oleuropein inhibits the reaction [Acrolein results in increased expression of BAX mRNA]; oleuropein inhibits the reaction [Acrolein results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]]PMID:29414845
Baxaffects localizationISOBAX (Homo sapiens)6480464CTDAcrolein affects the localization of BAX proteinPMID:19596284
Baxincreases expressionISOBax (Mus musculus)6480464CTDAcrolein results in increased expression of BAX proteinPMID:24376112
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDAcrolein results in increased expression of BAX mRNA; Acrolein results in increased expression of BAX proteinPMID:33421550 PMID:34958888
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDcapsazepine inhibits the reaction [Acrolein results in increased expression of BAX protein]; Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein]PMID:24376112
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of BAX mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of BAX mRNAPMID:32699268
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