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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15decreases expressionISOCXCL8 (Homo sapiens)6480464CTDAcrolein results in decreased expression of CXCL8 mRNA; Acrolein results in decreased expression of CXCL8 proteinPMID:15650393 PMID:18201443 PMID:28947239
Cxcl15decreases secretionISOCXCL8 (Homo sapiens)6480464CTDAcrolein results in decreased secretion of CXCL8 proteinPMID:28947239
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDAcrolein results in increased expression of CXCL8 mRNAPMID:18951912
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTDAcrolein results in increased secretion of CXCL8 proteinPMID:11504702 PMID:30204913
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTD[Acrolein co-treated with Formaldehyde co-treated with Ozone] results in increased expression of CXCL8 protein; Acrolein inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Acrolein inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Phenylbutyrates inhibits the reaction [Acrolein results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [Acrolein results in increased secretion of CXCL8 protein]PMID:11504702 PMID:15650393 PMID:16860297 PMID:18951912
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