GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cxcl15 | decreases expression | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | Acrolein results in decreased expression of CXCL8 mRNA; Acrolein results in decreased expression of CXCL8 protein | PMID:15650393 PMID:18201443 PMID:28947239 | Cxcl15 | decreases secretion | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | Acrolein results in decreased secretion of CXCL8 protein | PMID:28947239 | Cxcl15 | increases expression | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | Acrolein results in increased expression of CXCL8 mRNA | PMID:18951912 | Cxcl15 | increases secretion | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | Acrolein results in increased secretion of CXCL8 protein | PMID:11504702 PMID:30204913 | Cxcl15 | multiple interactions | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | [Acrolein co-treated with Formaldehyde co-treated with Ozone] results in increased expression of CXCL8 protein; Acrolein inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Acrolein inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Phenylbutyrates inhibits the reaction [Acrolein results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [Acrolein results in increased secretion of CXCL8 protein] | PMID:11504702 PMID:15650393 PMID:16860297 PMID:18951912 | |
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