GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | increases cleavage | EXP | | 6480464 | CTD | Acrolein results in increased cleavage of PARP1 protein | PMID:19596284 PMID:29964147 | PARP1 | multiple interactions | EXP | | 6480464 | CTD | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PARP1 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PARP1 mRNA; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Acrolein results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of PARP1 protein] | PMID:29964147 PMID:32699268 | PARP1 | increases cleavage | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Acrolein results in increased cleavage of PARP1 protein | PMID:31639409 | PARP1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased cleavage of PARP1 protein] | PMID:31639409 | |
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