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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDAcrolein results in decreased expression of BCL2 proteinPMID:24376112
Bcl2multiple interactionsEXP 6480464CTDcapsazepine inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]PMID:24376112
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDAcrolein results in decreased expression of BCL2 mRNA; Acrolein results in decreased expression of BCL2 proteinPMID:29414845
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDAcrolein results in decreased expression of BCL2 proteinPMID:34958888
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of BCL2 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein; Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]; oleuropein inhibits the reaction [Acrolein results in decreased expression of BCL2 mRNA]; oleuropein inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]]PMID:29414845
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