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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737428
Species: Homo sapiens
RGD Object: Gene
Symbol: GAB2
Name: GRB2 associated binding protein 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GAB2decreases expressionEXP 6480464CTDTretinoin results in decreased expression of GAB2 mRNAPMID:33167477
GAB2decreases response to substanceISOGab2 (Mus musculus)6480464CTDGAB2 protein results in decreased susceptibility to TretinoinPMID:16009726
GAB2increases expressionISOGab2 (Mus musculus)6480464CTDTretinoin results in increased expression of GAB2 proteinPMID:16009726
GAB2multiple interactionsISOGab2 (Mus musculus)6480464CTDFGF2 protein promotes the reaction [Tretinoin results in increased expression of GAB2 protein]; GAB2 protein promotes the reaction [FGF2 protein results in decreased susceptibility to Tretinoin]PMID:16009726
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