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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737222
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]PMID:22285649
Cyp17a1decreases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDTretinoin results in decreased expression of CYP17A1 mRNAPMID:14960491
Cyp17a1increases expressionISOCYP17A1 (Homo sapiens)6480464CTDTretinoin results in increased expression of CYP17A1 mRNAPMID:16621909
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