GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Shh | increases expression | EXP | | 6480464 | CTD | Tretinoin results in increased expression of SHH mRNA | PMID:26272751 | Shh | multiple interactions | EXP | | 6480464 | CTD | [Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of and results in increased activity of SHH protein; [Tretinoin co-treated with SHH protein] results in increased expression of NKX2-2 protein; [Tretinoin co-treated with SHH protein] results in increased expression of OLIG2 protein; SHH protein inhibits the reaction [Tretinoin results in increased expression of PAX7 protein]; SHH protein promotes the reaction [Tretinoin results in increased expression of BMP7 mRNA] | PMID:15996115 PMID:16860305 | Shh | multiple interactions | ISO | SHH (Homo sapiens) | 6480464 | CTD | [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GFRA1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFL protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFM protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NR4A2 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK3 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of PTCH1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of RBFOX3 protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of SYP protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH protein; [Tretinoin co-treated with SHH protein] results in increased expression of MNX1 mRNA; [Tretinoin co-treated with SHH protein] results in increased expression of MNX1 protein | PMID:17085092 PMID:17109623 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |