GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ALDH1A1 | decreases activity | EXP | | 6480464 | CTD | Tretinoin results in decreased activity of ALDH1A1 protein | PMID:16614850 | ALDH1A1 | decreases expression | EXP | | 6480464 | CTD | Tretinoin results in decreased expression of ALDH1A1 protein | PMID:16614850 | ALDH1A1 | multiple interactions | EXP | | 6480464 | CTD | [ALDH1A1 protein co-treated with SDR16C5 protein] results in increased chemical synthesis of Tretinoin; Tretinoin results in decreased expression of and results in decreased activity of ALDH1A1 protein | PMID:15470086 PMID:27793605 | ALDH1A1 | increases chemical synthesis | ISO | Aldh1a1 (Mus musculus) | 6480464 | CTD | ALDH1A1 protein results in increased chemical synthesis of Tretinoin | PMID:16207763 PMID:18831967 | ALDH1A1 | increases chemical synthesis | ISO | Aldh1a1 (Rattus norvegicus) | 6480464 | CTD | ALDH1A1 protein results in increased chemical synthesis of Tretinoin | PMID:17497177 PMID:21138835 | ALDH1A1 | increases expression | ISO | Aldh1a1 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased expression of ALDH1A1 mRNA | PMID:12834868 | ALDH1A1 | multiple interactions | ISO | Aldh1a1 (Mus musculus) | 6480464 | CTD | [DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in decreased expression of ALDH1A1 mRNA; [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of ALDH1A1 mRNA | PMID:24005908 PMID:36189433 | ALDH1A1 | multiple interactions | ISO | Aldh1a1 (Rattus norvegicus) | 6480464 | CTD | [DHRS9 protein affects the expression of ALDH1A1 mRNA] which affects the chemical synthesis of Tretinoin; [DHRS9 protein affects the expression of ALDH1A1 protein] which affects the chemical synthesis of Tretinoin | PMID:21138835 | |
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