GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CDKN1A | decreases expression | EXP | | 6480464 | CTD | Tretinoin results in decreased expression of CDKN1A mRNA | PMID:21924320 | CDKN1A | increases expression | EXP | | 6480464 | CTD | Tretinoin results in increased expression of CDKN1A; Tretinoin results in increased expression of CDKN1A mRNA; Tretinoin results in increased expression of CDKN1A protein | PMID:11519864 PMID:12130515 PMID:15254726 PMID:15695403 PMID:16140954 PMID:16223781 PMID:16461808 PMID:16752155 PMID:16765349 PMID:16766008 PMID:17138961 PMID:17349212 PMID:17431121 PMID:17656649 PMID:18922099 PMID:20507312 PMID:29743969 | CDKN1A | multiple interactions | EXP | | 6480464 | CTD | [N1-(2-aminophenyl)-N8-phenyloctanediamide co-treated with Tretinoin] results in increased expression of CDKN1A; [Tretinoin binds to and affects the activity of RARA protein] which results in increased activity of CDKN1A protein; [Tretinoin co-treated with Butyrates] results in increased expression of CDKN1A mRNA; [Tretinoin co-treated with CXCL12 protein] results in increased expression of CDKN1A protein; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CDKN1A mRNA; [Tretinoin co-treated with Hydrogen Peroxide] results in increased expression of CDKN1A protein; [Tretinoin co-treated with TGFB1 protein] results in increased expression of CDKN1A protein; CYP26A1 protein inhibits the reaction [[Tretinoin co-treated with Hydrogen Peroxide] results in increased expression of CDKN1A protein]; MIR106A mRNA inhibits the reaction [Tretinoin results in increased expression of CDKN1A mRNA]; romidepsin promotes the reaction [Tretinoin results in increased expression of CDKN1A mRNA]; Thiophenes analog promotes the reaction [Tretinoin results in increased expression of CDKN1A protein]; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein]; Tretinoin promotes the reaction [Butyrates results in increased expression of CDKN1A mRNA]; Tretinoin promotes the reaction [Butyrates results in increased expression of CDKN1A protein]; Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CDKN1A protein]; Tretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1A mRNA]; Tretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1A protein]; Tretinoin promotes the reaction [Vorinostat results in increased expression of CDKN1A mRNA]; Tretinoin promotes the reaction [Vorinostat results in increased expression of CDKN1A protein] | PMID:12130515 PMID:15703382 PMID:16140954 PMID:16223781 PMID:16242776 PMID:16765349 PMID:16766008 PMID:17327230 PMID:17341627 PMID:17431121 PMID:17656649 PMID:29743969 | CDKN1A | decreases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased expression of CDKN1A protein | PMID:15949692 | CDKN1A | increases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Tretinoin results in increased expression of CDKN1A protein | PMID:18425745 | | ||||||||||||||||||||||
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