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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732660
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF2R
Name: insulin like growth factor 2 receptor
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF2Rincreases expressionEXP 6480464CTDTretinoin results in increased expression of IGF2R mRNAPMID:33167477
IGF2Rmultiple interactionsEXP 6480464CTDTretinoin promotes the reaction [IGF2R binds to and results in increased secretion of IGF2 protein modified form]PMID:16680587
IGF2Rincreases expressionISOIgf2r (Rattus norvegicus)6480464CTDTretinoin results in increased expression of IGF2R proteinPMID:21433279
IGF2Rmultiple interactionsISOIgf2r (Rattus norvegicus)6480464CTDTretinoin inhibits the reaction [nitrofen results in decreased expression of IGF2R mRNA]PMID:21433279
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