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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDTretinoin results in increased phosphorylation of MAPK1 proteinPMID:17026715
Mapk1multiple interactionsEXP 6480464CTDU 0126 inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]PMID:17026715
Mapk1affects phosphorylationISOMAPK1 (Homo sapiens)6480464CTDTretinoin affects the phosphorylation of MAPK1 proteinPMID:21487212
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDTretinoin results in decreased phosphorylation of MAPK1 proteinPMID:20576349 PMID:31934280
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDTretinoin results in increased phosphorylation of MAPK1 proteinPMID:19635392
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of MAPK1 proteinPMID:16052510 PMID:16329108 PMID:16470170 PMID:17293044 PMID:19038232
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTD[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK1 protein; [Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of MAPK1 protein; [Quercetin co-treated with Tretinoin] results in decreased phosphorylation of MAPK1 protein; CAMK2B protein promotes the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [[Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of MAPK1 protein]; Tretinoin results in decreased phosphorylation of and results in decreased activity of MAPK1 proteinPMID:16043492 PMID:19635392 PMID:25203460
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]; [LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]; [Tretinoin co-treated with Genistein] results in increased phosphorylation of MAPK1 protein; [Tretinoin co-treated with Retinoids] results in increased phosphorylation of MAPK1 protein; ARL6IP5 protein affects the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]; arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]; Tretinoin promotes the reaction [CPG-oligonucleotide results in increased phosphorylation of MAPK1 protein]; Tretinoin results in increased phosphorylation of and affects the localization of and results in increased activity of MAPK1 protein; Tretinoin results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]PMID:15383624 PMID:16149052 PMID:16439309 PMID:16922813 PMID:17209053 PMID:17293044 PMID:20615082
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