GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PTGS2 | decreases expression | EXP | | 6480464 | CTD | Tretinoin results in decreased expression of PTGS2 mRNA; Tretinoin results in decreased expression of PTGS2 protein | PMID:15982314 PMID:16699180 | PTGS2 | increases expression | EXP | | 6480464 | CTD | Tretinoin metabolite results in increased expression of PTGS2 mRNA; Tretinoin results in increased expression of PTGS2 mRNA; Tretinoin results in increased expression of PTGS2 protein | PMID:15982314 PMID:16894348 | PTGS2 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; [Tretinoin co-treated with Lipopolysaccharides co-treated with trichostatin A] results in decreased expression of PTGS2 protein; [Tretinoin co-treated with Lipopolysaccharides] results in decreased expression of PTGS2 protein; Cycloheximide inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein] | PMID:16894348 PMID:16959971 | PTGS2 | affects activity | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Tretinoin affects the activity of PTGS2 protein | PMID:16847438 | PTGS2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Tretinoin results in increased expression of PTGS2 protein | PMID:16847436 | PTGS2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | [bisphenol A co-treated with Tretinoin] results in decreased expression of PTGS2 mRNA; [bisphenol F co-treated with Tretinoin] results in decreased expression of PTGS2 mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of PTGS2 mRNA | PMID:30951980 | |
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