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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2decreases expressionEXP 6480464CTDTretinoin results in decreased expression of PTGS2 mRNA; Tretinoin results in decreased expression of PTGS2 proteinPMID:15982314 PMID:16699180
PTGS2increases expressionEXP 6480464CTDTretinoin metabolite results in increased expression of PTGS2 mRNA; Tretinoin results in increased expression of PTGS2 mRNA; Tretinoin results in increased expression of PTGS2 proteinPMID:15982314 PMID:16894348
PTGS2multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; [Tretinoin co-treated with Lipopolysaccharides co-treated with trichostatin A] results in decreased expression of PTGS2 protein; [Tretinoin co-treated with Lipopolysaccharides] results in decreased expression of PTGS2 protein; Cycloheximide inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]PMID:16894348 PMID:16959971
PTGS2affects activityISOPtgs2 (Rattus norvegicus)6480464CTDTretinoin affects the activity of PTGS2 proteinPMID:16847438
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDTretinoin results in increased expression of PTGS2 proteinPMID:16847436
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of PTGS2 mRNA; [bisphenol F co-treated with Tretinoin] results in decreased expression of PTGS2 mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of PTGS2 mRNAPMID:30951980
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