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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf8
Name: fibroblast growth factor 8
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf8affects expressionISOFGF8 (Homo sapiens)6480464CTDTretinoin affects the expression of FGF8 mRNAPMID:31600526
Fgf8decreases expressionISOFgf8 (Mus musculus)6480464CTDTretinoin results in decreased expression of FGF8 mRNA; Tretinoin results in decreased expression of FGF8 proteinPMID:12588859 PMID:14623956 PMID:17551590
Fgf8decreases expressionISOFGF8 (Homo sapiens)6480464CTDTretinoin results in decreased expression of FGF8 mRNAPMID:21934132
Fgf8multiple interactionsISOFgf8 (Mus musculus)6480464CTDCYP26A1 protein inhibits the reaction [Tretinoin results in decreased expression of FGF8 mRNA]PMID:12588859
Fgf8multiple interactionsISOFGF8 (Homo sapiens)6480464CTD[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GFRA1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFL protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFM protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NR4A2 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK3 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of PTCH1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of RBFOX3 protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of SYP protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH proteinPMID:17085092
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