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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapt
Name: microtubule-associated protein tau
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maptincreases expressionEXP 6480464CTDTretinoin results in increased expression of MAPT proteinPMID:17130476
Maptaffects response to substanceISOMAPT (Homo sapiens)6480464CTDMAPT protein affects the susceptibility to TretinoinPMID:16417947
Maptdecreases expressionISOMAPT (Homo sapiens)6480464CTDTretinoin results in decreased expression of MAPT mRNAPMID:33167477
Maptincreases expressionISOMAPT (Homo sapiens)6480464CTDTretinoin results in increased expression of MAPT mRNA; Tretinoin results in increased expression of MAPT mRNA alternative form; Tretinoin results in increased expression of MAPT proteinPMID:23903816 PMID:26655721 PMID:9131769
Maptmultiple interactionsISOMAPT (Homo sapiens)6480464CTDMAPT protein promotes the reaction [Tretinoin affects the localization of MAPT protein]; Tretinoin promotes the reaction [MAPT protein affects the localization of [MAPT protein binds to RARG protein]]; Tretinoin promotes the reaction [ZMYND8 protein binds to MAPT gene]; Tretinoin promotes the reaction [ZMYND8 protein binds to MAPT promoter]; ZMYND8 protein affects the reaction [Tretinoin results in increased expression of MAPT mRNA]PMID:16417947 PMID:26655721
Maptmultiple interactionsISOMapt (Mus musculus)6480464CTDMAPT protein promotes the reaction [Tretinoin results in increased activity of CASP3 protein]PMID:16417947
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