GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Retn | decreases expression | ISO | Retn (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased expression of RETN mRNA; Tretinoin results in decreased expression of RETN protein | PMID:15047602 | Retn | decreases secretion | ISO | Retn (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased secretion of RETN protein | PMID:15047602 | Retn | increases expression | ISO | RETN (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased expression of RETN mRNA | PMID:17218384 PMID:33167477 | Retn | multiple interactions | ISO | RETN (Homo sapiens) | 6480464 | CTD | [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of and results in increased secretion of RETN protein; Tretinoin results in increased expression of and results in increased secretion of RETN protein; TRIB3 protein promotes the reaction [Tretinoin results in increased expression of and results in increased secretion of RETN protein] | PMID:32929351 | Retn | multiple interactions | ISO | Retn (Mus musculus) | 6480464 | CTD | Tretinoin inhibits the reaction [CEBPA protein binds to RETN promoter]; Tretinoin inhibits the reaction [CREBBP protein binds to RETN promoter]; Tretinoin inhibits the reaction [EP300 protein binds to RETN promoter]; Tretinoin inhibits the reaction [RB1 protein binds to RETN promoter] | PMID:15047602 | | ||||||||||||||||||||||
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