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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7314426480464CTDTretinoin results in decreased expression of CASP12 mRNA

PMID:22498432
multiple interactionsISORGD:13480776480464CTD[Tretinoin co-treated with Paclitaxel] results in increased expression of CASP12 protein

PMID:17701358
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.