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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxc2
Name: forkhead box C2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxc2decreases expressionISOFOXC2 (Homo sapiens)6480464CTDTretinoin results in decreased expression of FOXC2 mRNAPMID:31711903
Foxc2increases expressionISOFOXC2 (Homo sapiens)6480464CTDTretinoin results in increased expression of FOXC2 mRNAPMID:21934132
Foxc2multiple interactionsISOFOXC2 (Homo sapiens)6480464CTDTretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA]PMID:31711903
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