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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTretinoin results in decreased expression of COL1A2 mRNA

PMID:15234273
increases expressionEXP 6480464CTDTretinoin results in increased expression of COL1A2 mRNA

PMID:24977338
affects expressionISORGD:7309856480464CTDTretinoin affects the expression of COL1A2 mRNA

PMID:24704097
decreases expressionISORGD:7309846480464CTDTretinoin results in decreased expression of COL1A2 mRNA

PMID:23724009
decreases expressionISORGD:7309856480464CTDTretinoin results in decreased expression of COL1A2 mRNA

PMID:10729205
increases expressionISORGD:7309846480464CTDTretinoin results in increased expression of COL1A2 mRNA

PMID:21934132
multiple interactionsISORGD:7309856480464CTDTretinoin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], Tretinoin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]

PMID:10729205, PMID:17011172
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.