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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3742
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sparc
Name: secreted protein acidic and cysteine rich
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sparcincreases expressionEXP 6480464CTDTretinoin results in increased expression of SPARC mRNAPMID:24977338
Sparcaffects expressionISOSparc (Mus musculus)6480464CTDTretinoin affects the expression of SPARC mRNAPMID:24704097
Sparcdecreases expressionISOSPARC (Homo sapiens)6480464CTDTretinoin results in decreased expression of SPARC mRNAPMID:33167477
Sparcmultiple interactionsISOSparc (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of SPARC mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of SPARC mRNA; Tretinoin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]PMID:17994277 PMID:30951980
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