GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sp1 | increases activity | ISO | Sp1 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased activity of SP1 protein | PMID:17097063 | Sp1 | increases activity | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased activity of SP1 protein | PMID:16757381 | Sp1 | increases expression | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased expression of SP1 mRNA; Tretinoin results in increased expression of SP1 protein | PMID:23724009 PMID:26892147 PMID:33167477 | Sp1 | multiple interactions | ISO | SP1 (Homo sapiens) | 6480464 | CTD | arsenic trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein]; Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]; Tretinoin promotes the reaction [SP1 protein binds to HAS2 promoter]; Tretinoin promotes the reaction [SP1 protein binds to PDK4 promoter]; trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]] | PMID:16740727 PMID:16757381 PMID:17307735 PMID:26892147 | |
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