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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1increases activityISOSp1 (Mus musculus)6480464CTDTretinoin results in increased activity of SP1 proteinPMID:17097063
Sp1increases activityISOSP1 (Homo sapiens)6480464CTDTretinoin results in increased activity of SP1 proteinPMID:16757381
Sp1increases expressionISOSP1 (Homo sapiens)6480464CTDTretinoin results in increased expression of SP1 mRNA; Tretinoin results in increased expression of SP1 proteinPMID:23724009 PMID:26892147 PMID:33167477
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTDarsenic trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein]; Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]; Tretinoin promotes the reaction [SP1 protein binds to HAS2 promoter]; Tretinoin promotes the reaction [SP1 protein binds to PDK4 promoter]; trichostatin A promotes the reaction [Tretinoin promotes the reaction [SP1 protein binds to FOLR2 promoter]]PMID:16740727 PMID:16757381 PMID:17307735 PMID:26892147
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