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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3r1increases expressionISOPik3r1 (Mus musculus)6480464CTDTretinoin results in increased expression of PIK3R1 mRNA; Tretinoin results in increased expression of PIK3R1 proteinPMID:16288212
Pik3r1increases expressionISOPIK3R1 (Homo sapiens)6480464CTDTretinoin results in increased expression of PIK3R1 mRNAPMID:23830798 PMID:33167477
Pik3r1multiple interactionsISOPik3r1 (Mus musculus)6480464CTDPIK3R1 protein promotes the reaction [Tretinoin results in increased activity of AKT1 protein]PMID:16288212
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