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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDIL4 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]

PMID:11171635
decreases activityISORGD:7363066480464CTDIL4 protein results in decreased activity of Tretinoin

PMID:11171635
increases expressionISORGD:7363066480464CTDTretinoin results in increased expression of IL4 mRNA, Tretinoin results in increased expression of IL4 protein

PMID:15189689, PMID:16872382, PMID:17118196
increases secretionISORGD:7363066480464CTDTretinoin results in increased secretion of IL4 protein

PMID:16872382
multiple interactionsISORGD:7363066480464CTDRARA protein affects the reaction [Tretinoin results in increased secretion of IL4 protein], Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein], Tretinoin affects the reaction [IL4 protein results in increased expression of ALOX15 protein]

PMID:15996861, PMID:16872382
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.