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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2665
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gata4
Name: GATA binding protein 4
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata4affects expressionISOGATA4 (Homo sapiens)6480464CTDTretinoin affects the expression of GATA4 mRNAPMID:31600526 PMID:34742744
Gata4increases expressionISOGata4 (Mus musculus)6480464CTDTretinoin results in increased expression of GATA4 mRNAPMID:16236135 PMID:16604517 PMID:16619266
Gata4multiple interactionsISOGATA4 (Homo sapiens)6480464CTD[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA4 proteinPMID:23284745
Gata4multiple interactionsISOGata4 (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of GATA4 mRNAPMID:30951980
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