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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2321145
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxw7increases expressionISOFBXW7 (Homo sapiens)6480464CTDTretinoin results in increased expression of FBXW7 mRNA; Tretinoin results in increased expression of FBXW7 proteinPMID:30093655 PMID:33167477
Fbxw7multiple interactionsISOFBXW7 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of FBXW7 protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of FBXW7 protein]PMID:30093655
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