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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553810
Species: Mus musculus
RGD Object: Gene
Symbol: Bmp7
Name: bone morphogenetic protein 7
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTretinoin results in increased expression of BMP7 mRNA

PMID:15996115
multiple interactionsEXP 6480464CTDSHH protein promotes the reaction [Tretinoin results in increased expression of BMP7 mRNA], Tretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]

PMID:15996115, PMID:22285649
decreases expressionISORGD:13442346480464CTDTretinoin results in decreased expression of BMP7 mRNA

PMID:23724009, PMID:23830798
increases expressionISORGD:13442346480464CTDTretinoin results in increased expression of BMP7 mRNA

PMID:17196394
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.