Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1decreases expressionEXP 6480464CTDTretinoin results in decreased expression of POU5F1 mRNAPMID:30476341
Pou5f1affects expressionISOPOU5F1 (Homo sapiens)6480464CTDTretinoin affects the expression of POU5F1 mRNAPMID:31600526
Pou5f1decreases expressionISOPOU5F1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of POU5F1 mRNA; Tretinoin results in decreased expression of POU5F1 proteinPMID:16168501 PMID:17138961 PMID:21924320 PMID:22906706 PMID:34742744
Pou5f1decreases expressionISOPou5f1 (Mus musculus)6480464CTDTretinoin results in decreased expression of POU5F1 mRNA; Tretinoin results in decreased expression of POU5F1 proteinPMID:16415856 PMID:16448226 PMID:16574651 PMID:16845368 PMID:19135036 PMID:21111795
Pou5f1increases expressionISOPou5f1 (Mus musculus)6480464CTDTretinoin results in increased expression of POU5F1 proteinPMID:30442713
Pou5f1increases methylationISOPou5f1 (Mus musculus)6480464CTDTretinoin results in increased methylation of POU5F1 promoterPMID:16415856
Pou5f1multiple interactionsISOPou5f1 (Mus musculus)6480464CTDAGN 193109 inhibits the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]; EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]; EHMT2 protein promotes the reaction [Tretinoin results in increased methylation of POU5F1 promoter]; NR6A1 protein affects the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]; phenanthrene affects the reaction [Tretinoin results in decreased expression of POU5F1 protein]; Tretinoin promotes the reaction [[H3F4 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter]PMID:16166633 PMID:16415856 PMID:16574651 PMID:21111795
Go Back to source page   Continue to Ontology report