GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pou5f1 | decreases expression | EXP | | 6480464 | CTD | Tretinoin results in decreased expression of POU5F1 mRNA | PMID:30476341 | Pou5f1 | affects expression | ISO | POU5F1 (Homo sapiens) | 6480464 | CTD | Tretinoin affects the expression of POU5F1 mRNA | PMID:31600526 | Pou5f1 | decreases expression | ISO | POU5F1 (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased expression of POU5F1 mRNA; Tretinoin results in decreased expression of POU5F1 protein | PMID:16168501 PMID:17138961 PMID:21924320 PMID:22906706 PMID:34742744 | Pou5f1 | decreases expression | ISO | Pou5f1 (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased expression of POU5F1 mRNA; Tretinoin results in decreased expression of POU5F1 protein | PMID:16415856 PMID:16448226 PMID:16574651 PMID:16845368 PMID:19135036 PMID:21111795 | Pou5f1 | increases expression | ISO | Pou5f1 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased expression of POU5F1 protein | PMID:30442713 | Pou5f1 | increases methylation | ISO | Pou5f1 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased methylation of POU5F1 promoter | PMID:16415856 | Pou5f1 | multiple interactions | ISO | Pou5f1 (Mus musculus) | 6480464 | CTD | AGN 193109 inhibits the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]; EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]; EHMT2 protein promotes the reaction [Tretinoin results in increased methylation of POU5F1 promoter]; NR6A1 protein affects the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]; phenanthrene affects the reaction [Tretinoin results in decreased expression of POU5F1 protein]; Tretinoin promotes the reaction [[H3F4 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter] | PMID:16166633 PMID:16415856 PMID:16574651 PMID:21111795 | |
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