GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MEG3 | decreases methylation | ISO | Meg3 (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased methylation of MEG3 promoter | PMID:33493612 | MEG3 | increases expression | ISO | Meg3 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased expression of MEG3 mRNA | PMID:33493612 | MEG3 | multiple interactions | ISO | Meg3 (Mus musculus) | 6480464 | CTD | [bisphenol A co-treated with Tretinoin] results in increased expression of MEG3 mRNA; Tretinoin promotes the reaction [SMAD2 protein binds to MEG3 mRNA] | PMID:30951980 PMID:33493612 | |
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