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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346266
Species: Homo sapiens
RGD Object: Gene
Symbol: FAS
Name: Fas cell surface death receptor
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASdecreases expressionEXP 6480464CTDTretinoin results in decreased expression of FAS mRNA; Tretinoin results in decreased expression of FAS proteinPMID:16510162 PMID:17034753
FASincreases activityEXP 6480464CTDTretinoin results in increased activity of FAS proteinPMID:15703382
FASincreases expressionEXP 6480464CTDTretinoin results in increased expression of FAS mRNA; Tretinoin results in increased expression of FAS proteinPMID:16712844 PMID:16957513 PMID:20629322 PMID:34742744
FASmultiple interactionsEXP 6480464CTD[IFNG protein co-treated with Tretinoin] results in increased expression of FAS mRNA; [IFNG protein co-treated with Tretinoin] results in increased expression of FAS protein; [Tretinoin co-treated with Zoledronic Acid] results in increased expression of FAS protein; CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]PMID:15703382 PMID:16136269 PMID:20349282
FASmultiple interactionsISOFas (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of FAS mRNAPMID:30951980
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