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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322514
Species: Mus musculus
RGD Object: Gene
Symbol: Sox9
Name: SRY (sex determining region Y)-box 9
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox9decreases expressionEXP 6480464CTDTretinoin results in decreased expression of SOX9 mRNA; Tretinoin results in decreased expression of SOX9 proteinPMID:16505366 PMID:22498432 PMID:36189433
Sox9multiple interactionsEXP 6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of SOX9 mRNAPMID:36189433
Sox9decreases expressionISOSox9 (Rattus norvegicus)6480464CTDTretinoin results in decreased expression of SOX9 mRNA; Tretinoin results in decreased expression of SOX9 proteinPMID:23810783
Sox9increases expressionISOSOX9 (Homo sapiens)6480464CTDTretinoin results in increased expression of SOX9 mRNAPMID:16480812 PMID:23830798
Sox9multiple interactionsISOSOX9 (Homo sapiens)6480464CTD[Chir 99021 co-treated with BMP4 protein co-treated with FGF10 protein co-treated with FGF7 protein co-treated with Tretinoin] results in increased expression of SOX9 mRNAPMID:35267148
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