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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320714
Species: Mus musculus
RGD Object: Gene
Symbol: Foxl2
Name: forkhead box L2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxl2increases expressionEXP 6480464CTDTretinoin results in increased expression of FOXL2 mRNA; Tretinoin results in increased expression of FOXL2 proteinPMID:36189433
Foxl2multiple interactionsEXP 6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of FOXL2 mRNA; mono-(2-ethylhexyl)phthalate promotes the reaction [Tretinoin results in increased expression of FOXL2 protein]PMID:36189433
Foxl2increases expressionISOFoxl2 (Rattus norvegicus)6480464CTDTretinoin results in increased expression of FOXL2 mRNA; Tretinoin results in increased expression of FOXL2 proteinPMID:30329139 PMID:30476341
Foxl2increases expressionISOFOXL2 (Homo sapiens)6480464CTDTretinoin results in increased expression of FOXL2 mRNAPMID:21934132
Foxl2multiple interactionsISOFoxl2 (Rattus norvegicus)6480464CTDmono-(2-ethylhexyl)phthalate inhibits the reaction [Tretinoin results in increased expression of FOXL2 mRNA]PMID:30476341
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