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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317101
Species: Mus musculus
RGD Object: Gene
Symbol: Tbx1
Name: T-box 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbx1affects abundanceEXP 6480464CTDTBX1 gene mutant form affects the abundance of TretinoinPMID:16399080
Tbx1multiple interactionsEXP 6480464CTD[CRKL gene mutant form co-treated with TBX1 gene mutant form] affects the abundance of TretinoinPMID:16399080
Tbx1decreases expressionISOTBX1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of TBX1 mRNAPMID:33167477
Tbx1increases expressionISOTBX1 (Homo sapiens)6480464CTDTretinoin results in increased expression of TBX1 mRNAPMID:21934132
Tbx1multiple interactionsISOTBX1 (Homo sapiens)6480464CTD[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of BRACHYURY mRNAPMID:31711903
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