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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hoxd4
Name: homeo box D4
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13201726480464CTDTretinoin results in increased expression of HOXD4 mRNA

PMID:21934132
increases expressionISORGD:16151926480464CTDTretinoin results in increased expression of HOXD4 mRNA

PMID:16757478, PMID:19897914
multiple interactionsISORGD:16151926480464CTDTretinoin promotes the reaction [YY1 protein binds to HOXD4 promoter]

PMID:16757478
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.