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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302972
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ehmt2decreases expressionISOEHMT2 (Homo sapiens)6480464CTDTretinoin results in decreased expression of EHMT2 mRNAPMID:33167477
Ehmt2multiple interactionsISOEhmt2 (Mus musculus)6480464CTDEHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]; EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to ZFP42 promoter]]; EHMT2 protein promotes the reaction [Tretinoin results in increased methylation of POU5F1 promoter]PMID:16415856
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