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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12137992
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: CYP26A1
Name: cytochrome P450 family 26 subfamily A member 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP26A1increases degradationEXP 6480464CTDCYP26A1 protein results in increased degradation of TretinoinPMID:17035595
CYP26A1multiple interactionsEXP 6480464CTDCYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]PMID:17035595
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