Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11219
Species: Mus musculus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1decreases expressionEXP 6480464CTDTretinoin results in decreased expression of RB1 proteinPMID:15949692
Rb1decreases phosphorylationEXP 6480464CTDTretinoin results in decreased phosphorylation of RB1 proteinPMID:18425745
Rb1increases phosphorylationEXP 6480464CTDTretinoin results in increased phosphorylation of RB1 proteinPMID:15949692 PMID:16840543
Rb1multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [RB1 protein binds to RETN promoter]PMID:15047602
Rb1decreases expressionISORB1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of RB1 proteinPMID:12042460
Rb1decreases phosphorylationISORB1 (Homo sapiens)6480464CTDTretinoin results in decreased phosphorylation of RB1 proteinPMID:11519864 PMID:15126328 PMID:15194426 PMID:15383624 PMID:15695403 PMID:16140954 PMID:9158000
Rb1increases activityISORB1 (Homo sapiens)6480464CTDTretinoin results in increased activity of RB1 proteinPMID:15194426
Rb1increases expressionISORB1 (Homo sapiens)6480464CTDTretinoin results in increased expression of RB1 mRNA; Tretinoin results in increased expression of RB1 proteinPMID:15194426 PMID:15770638
Rb1increases phosphorylationISORB1 (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of RB1 proteinPMID:16920920
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTD[Tretinoin co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; CSF1R promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein]; PTK2 protein inhibits the reaction [Tretinoin promotes the reaction [CEBPA protein binds to RB1 protein]]; Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]]; Thiophenes analog promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein]; Tretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]; Tretinoin inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein]; Tretinoin promotes the reaction [CEBPA protein binds to RB1 protein]; Tretinoin promotes the reaction [CPG-oligonucleotide results in increased phosphorylation of RB1 protein]; Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]; Tretinoin results in increased expression of and results in decreased phosphorylation of RB1 proteinPMID:11348869 PMID:12421932 PMID:15194426 PMID:16140954 PMID:16226872 PMID:16242776 PMID:16565789 PMID:17209053 PMID:9158000
Go Back to source page   Continue to Ontology report