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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10742
Species: Mus musculus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein 5
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDTretinoin results in increased expression of HSPA5 mRNA; Tretinoin results in increased expression of HSPA5 proteinPMID:22498432
Hspa5decreases expressionISOHSPA5 (Homo sapiens)6480464CTDTretinoin results in decreased expression of HSPA5 mRNAPMID:23724009
Hspa5increases expressionISOHspa5 (Rattus norvegicus)6480464CTDTretinoin results in increased expression of HSPA5 mRNAPMID:20488242
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDTretinoin results in increased expression of HSPA5 mRNA; Tretinoin results in increased expression of HSPA5 proteinPMID:17031849 PMID:19960509 PMID:33167477
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDMGAT5 protein inhibits the reaction [Tretinoin results in increased expression of HSPA5 protein]PMID:17031849
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