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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2increases expressionEXP 6480464CTDAspirin results in increased expression of NOS2 proteinPMID:17218764
NOS2multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Aspirin results in increased expression of NOS2 protein]PMID:17218764
NOS2decreases expressionISONos2 (Mus musculus)6480464CTDAspirin results in decreased expression of NOS2 proteinPMID:10860828
NOS2decreases expressionISONos2 (Rattus norvegicus)6480464CTDAspirin results in decreased expression of NOS2 proteinPMID:16310244
NOS2multiple interactionsISONos2 (Mus musculus)6480464CTD[Aspirin results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric OxidePMID:10860828
NOS2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDAmpicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]PMID:21893697
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