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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68557
Species: Mus musculus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDAspirin results in decreased expression of CCND1 mRNA; Aspirin results in decreased expression of CCND1 proteinPMID:11313997 PMID:11593435 PMID:16878161 PMID:17357503 PMID:19595669 PMID:19966835 PMID:21721879
Ccnd1increases expressionISOCcnd1 (Rattus norvegicus)6480464CTDAspirin results in increased expression of CCND1 mRNAPMID:12800193
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDAspirin inhibits the reaction [Smoke analog results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein]PMID:15489888 PMID:16878161 PMID:19207549
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