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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621887
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkbib
Name: NFKB inhibitor beta
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbibmultiple interactionsISONFKBIB (Homo sapiens)6480464CTDAspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein]PMID:14753751 PMID:15036249
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